Endocrine Abstracts

Introduction: Measurement of the baseline level of 17-hydroxyprogesterone (17OHP) is a screening test for NCAH, a less severe form of congenital adrenal hyperplasia.Aim: A real-life verification of the currently adopted 17OHP threshold (≥2.0 ng/ml) at which the further diagnostic (cosyntropin stimulation test) should be performed.Material and methods: The study included 400 patients (385 females and 15 males) referred to the ...

Background: Screening algorithms for the identification of growth-disorders are routinely used in several countries. In the UK, the use of the Coventry consensus for the referral of children with suspected growth-disorders performs poorly compared to more sophisticated screening mechanisms used elsewhere. We aimed to test an algorithm developed to screen for growth-disorders in 2- to 8-year-old UK children.Methods: The a...

Introduction: 2-[18F]FDG PET/CT, commonly used for neoplastic lesions detection, also allows assessment of the severity of the inflammatory processes. Moreover, glucose uptake in spleen and bone marrow may be a useful biomarker of systemic inflammation. Patients with Cushing syndrome demonstrate many metabolic changes involving muscles and fat tissue. Some mechanisms are known, but their relationship to glucose metabolism is not well investigated. Our study aimed to correlate ...

Sarcoidosis is a systemic inflammatory disease of unknown etiology characterized by the formation of granulomas. It most often involves the lungs, although there are evidences that it can be presented in any organ. Involvement of the thyroid gland is a very rare manifestation, defined as below 1% of cases. Thyroid cancer, on the other hand, is a cancer occurring with a frequency of approximately 1-1, 3% of all cancers, but with an increased incidence associated with growing di...

Cell autonomous sex identity (CASI) of birds is the concept that sex-steroids have little or no effect on the development of secondary sexual characteristics in birds, and that sexual dimorphisms are determined by the sex-chromosome content of cells in individual tissues. In avian species males have a ZZ sex chromosome, while females are ZW. Sexual dimorphisms in chickens, such as muscle mass, comb and wattle size and hackles and spur development are believed to be determined ...

Introduction: The destination of young people referred from the NHS Gender Identity Development Service (GIDS) to the two paediatric endocrine centres covering England and Wales has not been analysed previously.Methods: 1151 young people identifying as gender variant were referred from GIDS for an endocrine opinion: 827 patients to University College London Hospital (UCLH) from 2008; 324 to Leeds Children’s Hospital (LCH) from 2013. Outcomes were no...

Background: Transplantation for cancer indications is evolving rapidly in UK and Ireland. Liver transplantation [LT] for unresectable neuroendocrine tumour liver metastases [NET LM] is one of three new cancer indications. It has the potential to significantly improve survival outcomes however, transplant benefit has likely been achieved only by highly experienced Centre(s). Since eligible patients for transplantation also have excellent prognosis with standard management, care...

Introduction: YDC is a partnership of four hospital trusts;Kings College Hospital, Princess Royal University Hospital, Lewisham University Hospital and Evelina London Children’s Hospital,caring for a total of 492 children and young people with diabetes. Most young people are on conventional long acting insulin (Levemir and Glargine), but increasingly, poorly controlled patients (HbA1C>100 mmol/mol) with high admission rates are being switched to insulin Degludec due t...

Introduction: Medullary thyroid carcinoma (MTC) accounts for 3.5-5% of thyroid cancers. The biochemical diagnosis of MTC is based on the determination of concentration of a sensitive and specific biomarker - calcitonin (CT) as well as CEA and procalcitonin (PCT). Neuroendocrine cells have the ability to produce various proteins and neuropeptides (e.g. granin proteins and INSM-1), which are secreted into the circulation with calcitonin and can be measured in the blood as so-cal...

Adrenal haemorrhage is a rare, usually life-threating complication, most commonly connected with primary or metastatic adrenal tumour. Among them pheochromocytoma is the most common cause of spontaneous adrenal bleeding and accounts for nearly 50% of cases. We performed a database search for pheochromocytoma patients, diagnosed and treated in Endocrinology Department, University Hospital in Cracow from 2005 to 2021. 206 patients with pheochromocytoma were identified. Subsequen...